We all knew this was coming and it has finally come. The final problem of offline access to web-based services has been addressed by Google Gears which was released last week. Today, I saw the first instance of it being available to the end user via the Google Reader.
You can have consistent, transparent access to all your favorite websites/web applications through the browser. The OS becomes less important now and the need for natively installed OS specific applications is greatly reduced.
It would be interesting to see the changes this will bring in our world!